A substance is a chemical element and its compounds in their natural state or the result of a manufacturing process.
In a manufacturing process, a chemical reaction is usually needed to form a substance.
Chemical (A) and chemical (B) are put together and react to form the substance C.
Compound C is a substance made by the reaction of A and B.

Examples of substances are:

• Metals
• Solvents, such as acetone
• Dyes and pigments
• Diesel and other fuels.
• REACH registration obligations only apply to substances.

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